Quercetin for Fibromyalgia

Quercetin /ˈkwɜrsɨtɨn/, a flavonol, is a plant-derived flavonoid found in fruits, vegetables, leaves and grains. It also may be used as an ingredient in supplements, beverages or foods.

http://en.wikipedia.org/wiki/Quercetin

 

Neuro-immunoendocrine disorder

Evidence exists that fibromyalgia is a neuro-immunoendocrine disorder. Elevations in substance P, IL-6 and IL-8 as well as corticotropin-releasing hormone have been found in thecerebral spinal fluid of fibromyalgia suffering individuals. Increased numbers of mast cell numbers have been found in skin biopsies of some individuals with fibromyalgia. Quercetin, apharmacologically active natural product which possesses anti-inflammatory in addition to mast cell inhibiting properties may be a useful treatment.^[67]

http://en.wikipedia.org/wiki/Fibromyalgia#Neuro-immunoendocrine_disorder

Quercetin (Photo credit: Wikipedia)

Adenosine Monophosphate Deaminase Deficiency, Fibromyalgia, and Ribose

Adenosine monophosphate deaminase deficiency type 1, also known as myoadenylate deaminase deficiency MADD, is a reasonably common recessive genetic metabolic disorder that shares many of the same symptoms as fibromyalgia, especially fatigue, cognitive dysfunction, and enhanced sensitivity to pain. Perhaps most telling are the studies showing a positive response to ribose, a possible treatment for MADD, by 66% of the test subjects diagnosed with fibromyalgia.[65][66]

via Fibromyalgia – Wikipedia, the free encyclopedia.

 

Ribose

Ribose is an organic compound with the formula C₅H₁₀O₅; specifically, a monosaccharide (simple sugar) with linear form H−(C=O)−(CHOH)₄−H, which has all the hydroxyl groups on the same side in the Fischer projection.

The term may refer to either of two enantiomers: it almost always refers to D-ribose, which occurs widely in nature and is discussed here; or to its synthetic mirror image L-ribose, which is not found in nature and is of limited interest.

D-Ribose was first reported in 1891 by Emil Fischer. It is a C’-2 carbon epimer of the sugar D–arabinose (both isomers of which are named for their source, gum arabic) and ribose itself is named as a transposition of the name of arabinose.^[3]

Ribose constitutes the backbone of RNA, a biopolymer that is the basis of genetic transcription. It is related to deoxyribose, as found in DNA. Once phosphorylated, ribose can become a subunit of ATP, NADH, and several other compounds that are critical to metabolism like the secondary messengers cAMP and cGMP.

http://en.wikipedia.org/wiki/Ribose

 

Riboflavin

Riboflavin, also known as vitamin B₂ is an easily absorbed colored micronutrient with a key role in maintaining health in humans and animals. It is the central component of the cofactors FAD and FMN, and is therefore required by all flavoproteins. As such, vitamin B₂is required for a wide variety of cellular processes. It plays a key role in energy metabolism, and for the metabolism of fats, ketone bodies, carbohydrates, and proteins.

Milk, cheese, leaf vegetables, liver, kidneys, legumes, yeast, mushrooms, and almonds^[2] are good sources of vitamin B₂, but exposure to light destroys riboflavin.

The name “riboflavin” comes from “ribose” (the sugar whose reduced form, ribitol, forms part of its structure) and “flavin“, the ring-moiety which imparts the yellow color to the oxidized molecule (from Latin flavus, “yellow”). The reduced form, which occurs in metabolism along with the oxidized form, is colorless.

http://en.wikipedia.org/wiki/Riboflavin